Background Colony-stimulating factor 1 receptor (CSF1R), a classic tyrosine kinase receptor, has been identified as a proto-oncogene in multiple cancers.The CSF1/CSF1R axis is essential for the survival and differentiation of M2-phenotype tumor-associated macrophages (M2 TAMs).However, we found here that the CSF1R expression was abnormally down-reg
Abstract Background Disorders of Sex Development (DSD) are a group of conditions associated with atypical development of internal and external genitalia.Identifying the underlying cause of DSD is crucial for diagnosis and long-term individualized approach for management and counselling.Social issues which are major obstacles in individuals with DSD
Emma R Berube, Cesar D Lopez, David P Trofa, Charles A Popkin Center for Shoulder, Elbow and Sports Medicine, Department of Orthopedics, Columbia University Medical Center, New York, NY, USACorrespondence: Charles A PopkinCenter for Shoulder, Elbow and Sports Medicine, Department of Orthopedics, Columbia University Medical Center, New York, NY, USA
Targeting defects in metabolism is an underutilized strategy for the treatment of cancer.Arginine auxotrophy resulting from the silencing of argininosuccinate synthetase 1 (ASS1) is a common metabolic alteration reported in a broad range of aggressive cancers.To assess the metabolic effects that arise from acute and chronic arginine starvation in A